| Display Channel | Digital Channel | Call Sign | Network | Nickname | Hours | Notes |
| WSIL-TV | HARRISBURG, IL | |||||
| 03-1 | 34.3 | WSILABC | ABC | "WSIL-TV 3" | ||
| K10KM-D | CAPE GIRARDEAU, MO | |||||
| 03-1 | 10.3 | WSILABC | ABC | "WSIL-TV 3" | ||
| WSIL-TV | HARRISBURG, IL | |||||
| 03-2 | 34.4 | HandI | Heroes & Icons | |||
| K10KM-D | CAPE GIRARDEAU, MO | |||||
| 03-2 | 10.4 | HandI | Heroes & Icons | |||
| 03-3 | 10.5 | TCN | True Crime Network | |||
| WSIL-TV | HARRISBURG, IL | |||||
| 03-3 | 34.5 | TCN | True Crime Network | |||
| K10KM-D | CAPE GIRARDEAU, MO | |||||
| 03-4 | 10.6 | CourtTV | Court TV | |||
| WSIL-TV | HARRISBURG, IL | |||||
| 03-4 | 34.6 | CourtTV | Court TV | |||
| K10KM-D | CAPE GIRARDEAU, MO | |||||
| 03-5 | 10.7 | Ion | ION | |||
| WSIL-TV | HARRISBURG, IL | |||||
| 03-5 | 34.7 | Ion | ION | |||
| WPSD-TV | PADUCAH, KY | |||||
| 06-1 | 19.3 | WPSD-HD | NBC | "WPSD Local 6" | ||
| 06-2 | 19.4 | COZI | COZI TV | |||
| 06-3 | 19.5 | CLASSIC | Antenna TV | |||
| WSIU-TV | CARBONDALE, IL | |||||
| 08-1 | 8.3 | WSIU | PBS | "WSIU" | ||
| 08-2 | 8.4 | WORLD | World Channel | |||
| 08-3 | 8.5 | CREATE | Create | |||
| 08-4 | 8.6 | KIDS247 | PBS Kids 24/7 | |||
| 08-5 | 8.7 | WSIU FM | Audio | "WSIU" | ||
| WQWQ-LD | PADUCAH, KY | |||||
| 09-1 | 18.1 | TELEMDO | Telemundo | |||
| 09-3 | 18.3 | DEFY | Defy TV | |||
| 09-4 | 18.4 | MeToons | Me-TV Toons | |||
| K17LV-D | POPLAR BLUFF, MO | |||||
| 12-1 | 17.3 | KFVS DT | CBS | "KFVS 12" | ||
| KFVS-TV | CAPE GIRARDEAU, MO | |||||
| 12-1 | 11.3 | KFVS DT | CBS | "KFVS 12" | ||
| K17LV-D | POPLAR BLUFF, MO | |||||
| 12-2 | 17.4 | CW | CW | "Heartland's CW" | ||
| KFVS-TV | CAPE GIRARDEAU, MO | |||||
| 12-2 | 11.4 | CW | CW | "Heartland's CW" | ||
| K17LV-D | POPLAR BLUFF, MO | |||||
| 12-3 | 17.5 | KFVSOUT | Outlaw | |||
| KFVS-TV | CAPE GIRARDEAU, MO | |||||
| 12-3 | 11.5 | KFVSOUT | Outlaw | |||
| K17LV-D | POPLAR BLUFF, MO | |||||
| 12-4 | 17.6 | MeTV | Me-TV | |||
| KFVS-TV | CAPE GIRARDEAU, MO | |||||
| 12-4 | 11.6 | MeTV | Me-TV | |||
| K17LV-D | POPLAR BLUFF, MO | |||||
| 12-5 | 17.7 | Grit | Grit | |||
| KFVS-TV | CAPE GIRARDEAU, MO | |||||
| 12-5 | 11.7 | Grit | Grit | |||
| K17LV-D | POPLAR BLUFF, MO | |||||
| 12-6 | 17.8 | Oxygen | Oxygen | |||
| KFVS-TV | CAPE GIRARDEAU, MO | |||||
| 12-6 | 11.8 | Oxygen | Oxygen | |||
| K17LV-D | POPLAR BLUFF, MO | |||||
| 12-7 | 17.9 | 365BLK | 365BLK | |||
| KFVS-TV | CAPE GIRARDEAU, MO | |||||
| 12-7 | 11.9 | 365BLK | 365BLK | |||
| KPOB-TV | POPLAR BLUFF, MO | |||||
| 15-1 | 15.3 | KPOB-TV | ABC | "WSIL-TV 3" | ||
| W15BU-D | JOHNSON CITY, IL | |||||
| 15-1 | 15.3 | W15BU-D | 3ABN | |||
| KPOB-TV | POPLAR BLUFF, MO | |||||
| 15-2 | 15.4 | KPOB-TV | Heroes & Icons | |||
| W15BU-D | JOHNSON CITY, IL | |||||
| 15-2 | 15.4 | 3ABN-PR | 3ABN Proclaim | |||
| KPOB-TV | POPLAR BLUFF, MO | |||||
| 15-3 | 15.5 | KPOB-TV | True Crime Network | |||
| W15BU-D | JOHNSON CITY, IL | |||||
| 15-3 | 15.5 | 3ABN-DD | 3ABN Dare to Dream | |||
| KPOB-TV | POPLAR BLUFF, MO | |||||
| 15-4 | 15.6 | KPOB-TV | Court TV | |||
| W15BU-D | JOHNSON CITY, IL | |||||
| 15-4 | 15.6 | 3ABN-ES | 3ABN Latino | |||
| 15-5 | 15.7 | 3ABN-KD | 3ABN Kids | |||
| KPOB-TV | POPLAR BLUFF, MO | |||||
| 15-5 | 15.7 | Ion | ION | |||
| KDKZ-LD | FARMINGTON, MO | |||||
| 18-1 | 22.1 | kdkz | Independent | "Main Street TV" | ||
| WKMU | MURRAY, KY | |||||
| 21-1 | 17.3 | KET | PBS | "KET" | ||
| 21-2 | 17.4 | KET2 | PBS Encore | "KET2" | ||
| 21-3 | 17.5 | KET KY | Kentucky Channel | "KET KY" | ||
| 21-4 | 17.6 | KETKIDS | PBS Kids 24/7 | |||
| KBSI | CAPE GIRARDEAU, MO | |||||
| 23-1 | 36.3 | KBSI-DT | FOX | "Fox 23" | ||
| 23-2 | 36.4 | WDKA-DT | MyN | "My 49" | ||
| 23-3 | 36.5 | COMET | Comet TV | |||
| 23-4 | 36.6 | DEFY | ION Plus | |||
| 23-5 | 36.7 | BOUNCE | Bounce TV | |||
| 23-6 | 36.8 | SC NEWS | Scripps News | |||
| WUWT-LD | UNION CITY, TN | |||||
| 26-1 | 24.1 | WUWT-DT | Retro TV | "News 26" | ||
| 26-2 | 24.2 | WUWT-2 | Heartland | |||
| WTCT | MARION, IL | |||||
| 27-01 | 30.3 | WTCT HD | TCT | |||
| 27-02 | 30.4 | SBN | SonLife | |||
| 27-03 | 30.5 | Positiv | Positiv | |||
| 27-04 | 30.6 | LAFF | Laff | |||
| 27-05 | 30.7 | StartTV | Start TV | |||
| 27-06 | 30.8 | StoryTV | Story Television | |||
| 27-07 | 30.9 | Quest | Quest | |||
| 27-08 | 30.10 | BuzzrTV | BUZZR | |||
| 27-09 | 30.11 | BizTV | Biz TV | |||
| 27-10 | 30.12 | ShopLC | Shop LC | |||
| 27-11 | 30.13 | WEST | West | |||
| WKPD | PADUCAH, KY | |||||
| 29-1 | 23.3 | KET | PBS | "KET" | ||
| 29-2 | 23.4 | KET2 | PBS Encore | "KET2" | ||
| 29-3 | 23.5 | KET KY | Kentucky Channel | "KET KY" | ||
| 29-4 | 23.6 | KETKIDS | PBS Kids 24/7 | |||
| WDKA | PADUCAH, KY | |||||
| 49-1 | 25.3 | MyTV | MyN | "My 49" | ||
| 49-2 | 25.4 | Charge! | Charge! | |||
| 49-3 | 25.5 | TBD | ROAR | |||
| 49-4 | 25.6 | Stadium | The Nest | |||
| 49-5 | 25.7 | Dabl | Dabl | |||
| 49-6 | 25.8 | CourtTV | Court TV | |||
| 49-7 | 25.9 | CHSN | CHSN | |||