| Display Channel | Digital Channel | Call Sign | Network | Nickname | Hours | Notes |
| WIS | COLUMBIA, SC | |||||
| 10-1 | 10.3 | WIS-NBC | NBC | "WIS 10" | ||
| 10-2 | 10.4 | WIS-CW | CW | |||
| 10-3 | 10.5 | Bounce | Bounce TV | |||
| 10-4 | 10.6 | WISPSN | Palmetto Sports & Entertainment | |||
| 10-5 | 10.7 | Oxygen | Oxygen | |||
| 10-6 | 10.8 | Outlaw | Outlaw | |||
| 10-7 | 10.9 | The365 | 365BLK | |||
| WPAM-LD | Lexington, SC | |||||
| 16-1 | 18.3 | WTES | Telemundo | |||
| WTES-LD | COLUMBIA, SC | |||||
| 16-1 | 35.3 | WTES | Telemundo | |||
| WPAM-LD | Lexington, SC | |||||
| 16-2 | 18.4 | WTESPSN | Palmetto Sports & Entertainment | |||
| WTES-LD | COLUMBIA, SC | |||||
| 16-2 | 35.4 | WTESPSN | Palmetto Sports & Entertainment | |||
| WPAM-LD | Lexington, SC | |||||
| 16-3 | 18.5 | WTESDFY | Defy TV | |||
| WTES-LD | COLUMBIA, SC | |||||
| 16-3 | 35.5 | WTESDFY | Defy TV | |||
| WLTX | COLUMBIA, SC | |||||
| 19-1 | 15.3 | WLTX-HD | CBS | "WLTX 19" | ||
| 19-2 | 15.4 | Crime | True Crime Network | |||
| 19-3 | 15.5 | ShopLC | Shop LC | |||
| 19-4 | 15.6 | Quest | Quest | |||
| 19-5 | 15.7 | NEST | The Nest | |||
| 19-6 | 15.8 | NOSEY | Nosey | |||
| 19-7 | 15.9 | CONFESS | Confess | |||
| 19-8 | 15.10 | OPEN | [Blank] | |||
| WOLO-TV | COLUMBIA, SC | |||||
| 25-1 | 7.3 | WOLO-DT | ABC | "ABC Columbia" | ||
| 25-2 | 7.4 | WOLO-ST | Start TV | |||
| 25-3 | 7.5 | QVC-TV | QVC | |||
| 25-4 | 7.6 | WOLO-ME | Me-TV | |||
| 25-5 | 7.7 | WOLO-HI | Heroes & Icons | |||
| 25-6 | 7.8 | WOLO-DB | Dabl | |||
| 25-7 | 7.9 | WOLO-GT | Story Television | |||
| 25-8 | 7.10 | HSN-TV | HSN | |||
| 25-9 | 7.11 | MeTOONS | Me-TV Toons | |||
| WRJA-TV | SUMTER, SC | |||||
| 27-1 | 29.1 | ETV | PBS | "ETV" | ||
| 27-2 | 29.2 | SCC | PBS Encore | "SC Channel" | 06p-12a | |
| 27-2 | 29.2 | SCC | Create | "SC Channel" | 12a-06p | |
| 27-3 | 29.3 | ETVW | PBS Encore | "ETV World" | ||
| 27-4 | 29.4 | ETVK | PBS Kids 24/7 | |||
| WRLK-TV | COLUMBIA, SC | |||||
| 35-1 | 33.1 | ETV | PBS | "ETV" | ||
| 35-2 | 33.2 | SCC | PBS Encore | "SC Channel" | 06p-12a | |
| 35-2 | 33.2 | SCC | Create | "SC Channel" | 12a-06p | |
| 35-3 | 33.3 | ETVW | PBS Encore | "ETV World" | ||
| 35-4 | 33.4 | ETVK | PBS Kids 24/7 | |||
| WZRB | COLUMBIA, SC | |||||
| 47-1 | 25.3 | ION | ION | |||
| 47-2 | 25.4 | CourtTV | Court TV | |||
| 47-3 | 25.5 | Mystery | ION Mystery | |||
| 47-4 | 25.6 | IONPlus | ION Plus | |||
| 47-5 | 25.7 | Catchy | Catchy Comedy | |||
| 47-6 | 25.8 | BUSTED | Busted | |||
| 47-7 | 25.9 | GameSho | Game Show Central | |||
| 47-8 | 25.10 | QVC2 | QVC2 | |||
| 47-9 | 25.11 | HSN2 | HSN2 | |||
| WKDC-LD | COLUMBIA, SC | |||||
| 50-1 | 16.1 | WKDC | Daystar | |||
| 50-2 | 16.2 | Espanol | Daystar Español | |||
| 50-3 | 16.3 | 50.3 | Daystar Reflections | |||
| WACH | COLUMBIA, SC | |||||
| 57-1 | 22.3 | FOX | FOX | "WACH Fox" | ||
| 57-2 | 22.4 | ROAR | ROAR | |||
| 57-3 | 22.5 | CHARGE! | Charge! | |||
| 57-4 | 22.6 | Comet | Comet TV | |||
| 57-5 | 22.7 | TheNest | The Nest | |||
| WKTC | SUMTER, SC | |||||
| 63-1 | 31.1 | WKTC-HD | MyN | |||
| 63-2 | 31.2 | AmCrime | NBC True CRMZ | |||
| 63-3 | 31.3 | CoziTV | COZI TV | |||
| 63-4 | 31.4 | LaffTV | Laff | |||
| 63-5 | 31.5 | GritTV | Grit | |||
| 63-6 | 31.6 | GetTV | GET | |||